And his math skills.No. I love his knowledge
FLOGGY. THIS IS FOR YOU. IT'S THE NE JOURNAL OF MEDICINE. SCIENCE.
I know it's a lot of really big words. Take your time.
COVID survivors with natural immunity at low risk for reinfection or severe symptoms
View attachment 7051
Using national, federated databases that have captured all SARS-CoV-2–related data since the onset of the pandemic (Section S1 in the Supplementary Appendix, available with the full text of this letter at NEJM.org), we investigated the risk of severe disease (leading to acute care hospitalization), critical disease (leading to hospitalization in an intensive care unit [ICU]), and fatal disease caused by reinfections as compared with primary infections in the national cohort of 353,326 persons with polymerase-chain-reaction (PCR)–confirmed infection between February 28, 2020, and April 28, 2021, after exclusion of 87,547 persons with a vaccination record. Primary infection was defined as the first PCR-positive swab. Reinfection was defined as the first PCR-positive swab obtained at least 90 days after the primary infection. Persons with reinfection were matched to those with primary infection in a 1:5 ratio according to sex, 5-year age group, nationality, and calendar week of the PCR test date (Fig. S1 and Table S1 in the Supplementary Appendix). Classification of severe, critical, and fatal Covid-19 followed World Health Organization guidelines, and assessments were made by trained medical personnel through individual chart reviews.
Of 1304 identified reinfections, 413 (31.7%) were caused by the B.1.351 variant (subsequent variants), 57 (4.4%) by the B.1.1.7 variant (Alpha), 213 (16.3%) by “wild-type” virus, and 621 (47.6%) were of unknown status (Section S1 in the Supplementary Appendix). For reinfected persons, the median time between first infection and reinfection was 277 days (interquartile range, 179 to 315). The odds of severe disease at reinfection were 0.12 times (95% confidence interval [CI], 0.03 to 0.31) that at primary infection (Table 1). There were no cases of critical disease at reinfection and 28 cases at primary infection (Table S3), for an odds ratio of 0.00 (95% CI, 0.00 to 0.64). There were no cases of death from Covid-19 at reinfection and 7 cases at primary infection, resulting in an odds ratio of 0.00 (95% CI, 0.00 to 2.57). The odds of the composite outcome of severe, critical, or fatal disease at reinfection were 0.10 times (95% CI, 0.03 to 0.25) that at primary infection. Sensitivity analyses were consistent with these results (Table S2).
Reinfections had 90% lower odds of resulting in hospitalization or death than primary infections. Four reinfections were severe enough to lead to acute care hospitalization. None led to hospitalization in an ICU, and none ended in death. Reinfections were rare and were generally mild, perhaps because of the primed immune system after primary infection.
In earlier studies, we assessed the efficacy of previous natural infection as protection against reinfection with SARS-CoV-22,3 as being 85% or greater. Accordingly, for a person who has already had a primary infection, the risk of having a severe reinfection is only approximately 1% of the risk of a previously uninfected person having a severe primary infection. It needs to be determined whether such protection against severe disease at reinfection lasts for a longer period, analogous to the immunity that develops against other seasonal “common-cold” coronaviruses,4 which elicit short-term immunity against mild reinfection but longer-term immunity against more severe illness with reinfection. If this were the case with SARS-CoV-2, the virus (or at least the variants studied to date) could adopt a more benign pattern of infection when it becomes endemic.4
View attachment 7052
As the vaccines wane, it continues to appear that natural immunity is our strongest defense.
I’m quite certain it has primarily to do with their very low vaccination rate. The ICU docs who were commenting on the prevalence of obesity in Covid patients prior to the vaccine are now commenting on the prevalence of the unvaccinated.Have you thought it may be about the overall fitness of West Virginians versus Israelis? I would bet good money on the obesity rate being far higher in WV than in Israel. That is the single biggest linked factor between cases and deaths.
We already knew it, but Fauci outed himself as a typical, partisan bureaucrat. **** him.
Listen to this guy.....
I’m quite certain it has primarily to do with their very low vaccination rate.
I’m quite certain it has primarily to do with their very low vaccination rate.
The ICU docs who were commenting on the prevalence of obesity in Covid patients prior to the vaccine are now commenting on the prevalence of the unvaccinated.
West Virginia’s hillbillies make poor health decisions be it diet and exercise or whether to get vaccinated or not.
I know. That tool who is a professor at Johns Hopkins Medical School. Wrote an opinion piece based upon the science of the time.Oh, please! Tim was listening to that ******* tool back when he was making this claim…
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Opinion | We’ll Have Herd Immunity by April
Covid cases have dropped 77% in six weeks. Experts should level with the public about the good news.www.wsj.com
Get well soon.so tying in a couple of threads here. so i am vaxxed/boosted and now have covid. 10 days quarantined but........ i dont feel bad, and I have so much food/water etc stocked away that it will not be an issue. always be prepared!!
ps need a couple good shows to watch if you have any ideas
Did you get a rapid test or PCR test? We had a lady at work who had bad respiratory symptoms. She was tested for 3 days and came back negative. The third day after work she went to hospital and ended up testing positive with COVID pneumonia. Luckily she was only in the hospital about a day total. Hopefully you and your wife feel better but if the symptoms persist I would get re-tested in a couple days.Wife and I are both covid negative. Gonna go see my doctor and hopefully get a zpack or something to knock this cough out.
Barry Bonds is toastI have heard it will kill if your head is to obese.
CDC is already calling for boosters for Omicron. This is insane. **** is never going away. Best you can do is take the steps you feel necessary and live your life. If you really are going to die, why go out with regrets?
so tying in a couple of threads here. so i am vaxxed/boosted and now have covid. 10 days quarantined but........ i dont feel bad, and I have so much food/water etc stocked away that it will not be an issue. always be prepared!!
ps need a couple good shows to watch if you have any ideas
WE? are you working at Pfizer or Monderna as a virologist? lol...I highly doubt that. You can't pen a constructed sentence properly.With at least 30 mutations to the virus expect a bad happening coming but way. The question is, will the vaccine be enough or will we need to develop another one?
That’s great, Tim. These people can hang their hat on that…FLOGGY. THIS IS FOR YOU. IT'S THE NE JOURNAL OF MEDICINE. SCIENCE.
I know it's a lot of really big words. Take your time.
COVID survivors with natural immunity at low risk for reinfection or severe symptoms
View attachment 7051
Using national, federated databases that have captured all SARS-CoV-2–related data since the onset of the pandemic (Section S1 in the Supplementary Appendix, available with the full text of this letter at NEJM.org), we investigated the risk of severe disease (leading to acute care hospitalization), critical disease (leading to hospitalization in an intensive care unit [ICU]), and fatal disease caused by reinfections as compared with primary infections in the national cohort of 353,326 persons with polymerase-chain-reaction (PCR)–confirmed infection between February 28, 2020, and April 28, 2021, after exclusion of 87,547 persons with a vaccination record. Primary infection was defined as the first PCR-positive swab. Reinfection was defined as the first PCR-positive swab obtained at least 90 days after the primary infection. Persons with reinfection were matched to those with primary infection in a 1:5 ratio according to sex, 5-year age group, nationality, and calendar week of the PCR test date (Fig. S1 and Table S1 in the Supplementary Appendix). Classification of severe, critical, and fatal Covid-19 followed World Health Organization guidelines, and assessments were made by trained medical personnel through individual chart reviews.
Of 1304 identified reinfections, 413 (31.7%) were caused by the B.1.351 variant (subsequent variants), 57 (4.4%) by the B.1.1.7 variant (Alpha), 213 (16.3%) by “wild-type” virus, and 621 (47.6%) were of unknown status (Section S1 in the Supplementary Appendix). For reinfected persons, the median time between first infection and reinfection was 277 days (interquartile range, 179 to 315). The odds of severe disease at reinfection were 0.12 times (95% confidence interval [CI], 0.03 to 0.31) that at primary infection (Table 1). There were no cases of critical disease at reinfection and 28 cases at primary infection (Table S3), for an odds ratio of 0.00 (95% CI, 0.00 to 0.64). There were no cases of death from Covid-19 at reinfection and 7 cases at primary infection, resulting in an odds ratio of 0.00 (95% CI, 0.00 to 2.57). The odds of the composite outcome of severe, critical, or fatal disease at reinfection were 0.10 times (95% CI, 0.03 to 0.25) that at primary infection. Sensitivity analyses were consistent with these results (Table S2).
Reinfections had 90% lower odds of resulting in hospitalization or death than primary infections. Four reinfections were severe enough to lead to acute care hospitalization. None led to hospitalization in an ICU, and none ended in death. Reinfections were rare and were generally mild, perhaps because of the primed immune system after primary infection.
In earlier studies, we assessed the efficacy of previous natural infection as protection against reinfection with SARS-CoV-22,3 as being 85% or greater. Accordingly, for a person who has already had a primary infection, the risk of having a severe reinfection is only approximately 1% of the risk of a previously uninfected person having a severe primary infection. It needs to be determined whether such protection against severe disease at reinfection lasts for a longer period, analogous to the immunity that develops against other seasonal “common-cold” coronaviruses,4 which elicit short-term immunity against mild reinfection but longer-term immunity against more severe illness with reinfection. If this were the case with SARS-CoV-2, the virus (or at least the variants studied to date) could adopt a more benign pattern of infection when it becomes endemic.4
View attachment 7052
As the vaccines wane, it continues to appear that natural immunity is our strongest defense.
Within the first 48 hrs of onset of symptomsIsn’t it within the first 72hr